12/17/2023 0 Comments Caffeine withdrawal symptoms ncbi![]() ![]() The regular caffeine users switched between a maintenance dose of 400 mg of caffeine or a placebo without any caffeine, and at regular points received either high dose caffeine or placebo challenges. While the study was small, only 16 subjects, it was double-blinded (neither the subjects nor the researchers know which treatment a person is on) which is the gold standard. Published by researchers from the University of Vermont and Johns Hopkins University School of Medicine, which you can read here if you’re interested in understanding everything. There’s actually a really nice study which looks at just this effect. But I wanted to real scoop on what causes withdrawal, so I asked, you guessed it, Aaron, the badass scientist on our team. I’d read that coffee constricts blood vessels in the brain, and that when you quit, the passageways open back up, which causes a headache. ![]() It got me wondering, did my CYP1A2 genotype have something to do with the severity of my withdrawal? I stayed in bed a good chunk of the day and got very little done.Īs I clicked off more caffeine free days on the calendar, I returned to normal, but the experience of having a true withdrawal from an actual drug was a first for me and it was eye opening.
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